Building blocks of blood vessels found to be associated with inflammation and disease processes in male mice
A newly published study from York University sheds light on the biological underpinnings in sex differences in obesity-related disease, with researchers observing “striking” differences in the cells that build blood vessels in the fatty tissue of male versus female mice.
Men are more likely than women to develop conditions associated with obesity such as cardiovascular disease, insulin resistance and diabetes, says York Professor Tara Haas with the Faculty of Health’s School of Kinesiology and Health Science.
“People have used rodent models to study obesity, and the diseases that are associated with obesity — like diabetes — but they’ve typically always studied male rodents, because females are resistant to developing the same kinds of diseases,” says Haas, lead on the study. “We were really interested in exploring that difference because, to us, it spoke of something really fascinating happening in females that protects them.”
Haas and her team observed in an earlier study that when mice become obese, females grow a lot of new blood vessels to supply the expanding fat tissue with oxygen and nutrients, whereas males grow a lot less. In this latest study published in iScience, Haas and her co-authors, including York PhD student Alexandra Pislaru, Faculty of Health Assistant Professor Emilie Roudier, and former York post-doctorate student Martina Rudnicki, focused on differences in the endothelial cells that make up the building blocks of these blood vessels in fat tissue.
Female endothelial cells replicated faster, while male endothelial cells displayed greater sensitivity to an inflammatory stimulus. By comparing with previously published data sets, the researchers found endothelial cells from aged male mice also displayed a more inflammatory profile compared to female cells.
“You can’t make the assumption that both sexes are going to respond to the same series of events the same way,” says Haas. “This isn’t just an obesity related issue — I think it’s a much broader conceptual problem that also encompasses healthy aging. One implication of our findings is that there will be situations where the treatment that is ideal for men is not going to be ideal for women and vice-versa.”
The study was funded by a grant through the Canadian Institutes of Health Research, as well as the Natural Science and Engineering Research Council of Canada and York’s Faculty of Health.
While humans and mice have different genes that may be turned up or down, Haas believes the general findings would likely apply and is interested studying the same cells in humans in future research.